Self-Assembled Monolayers Derived from Positively Charged Adsorbates on Plasmonic Substrates for MicroRNA Delivery: A Review

MicroRNA (miRNA) has emerged as a promising alternative therapeutic treatment for cancer, but its delivery been hindered by low cellular uptake and degradation during circulation. In this review, we discuss the various methods of delivering miRNA, including viral non-viral systems such liposomes nanoparticles. We also examine use nanoparticles miRNA-based diagnostics. focus specifically on utilizing coinage metals in form self-assembled monolayers (SAMs) method surface modification. review SAMs conjugation small noncoding ribonucleic acid (ncRNA), particularly derived from positively charged adsorbates to generate surfaces that can interact electrostatically with negatively miRNA. effects gold other plasmonic nanoparticles, well challenges associated oligonucleotides. Our highlights potential SAM-based versatile robust tools miRNA RNAs vitro vivo need further research address